Jolie asked that she get full physical custody of the couple's children, according to TMZ. Jolie and Pitt have six children together -- three adopted and three biological -- between the ages of 8 and 15 years old.
Robert Offer, an attorney for Jolie, told The Associated Press his client filed for dissolution of the marriage "for the health of the family."
Jolie listed Sept. 15, 2016, as the couple's separation date, TMZ reported.
"I am very saddened by this, but what matters most now is the well-being of our kids," Pitt said in a statement to PEOPLE. "I kindly ask the press to give them the space they deserve during this challenging time."